Presentation
12.5g/50mL
Role
- Management of severe cyanide poisoning evidenced by altered level of consciousness, seizures, hypotension or significant acidosis.
- Must be given with either hydroxocobalamin (preferred) or sodium nitrite.
Consultation with a clinical toxicologist is recommended through the local toxicology service or Poisons Information Centre 13 11 26.
Dose
12.5g IV (child 400mg/kg) in 200mL 5% glucose over 30 min.
Stocking recommendations
| Tertiary centre | Regional centre | Rural centre | Remote centre |
|---|---|---|---|
| 2 | 2 | 0-2 | 0 |
Rationale
If available, hydroxocobalamin is the preferred antidote for cyanide poisoning. Sodium thiosulfate plus sodium nitrite are an acceptable alternative if hydroxocobalamin is unavailable.
Disclaimer
Fact sheet developed by Queensland Poisons Information Centre.
This fact sheet is about the use of these antidotes in Australia, and may not apply to other countries. Children’s Health Queensland Hospital and Health Service cannot be held responsible for the accuracy of information, omissions of information, or any actions that may be taken as a consequence of reading this fact sheet.